Pengaruh Variasi HA-TCP (Hydroxy Apatit-Tricalcium Pospat) Terhadap Biokomposit (HA:TCP)-Gelatin-CMC Sebagai Injectable Bone Subtitute (IBS)

Gani Purwiandono, Hera Julita, Dita Adi Saputra

Abstract

The synthesis of biocomposite (HA:TCP) – Gelatine – CMC for bone filler material has been carried out. In this research, the ratio of HA and TCP was varied as follows: 70:30, 50:50 and 40:60. The decrease of HA and the increase of TCP concentration will decrease the density, increase the percentage of porosity and swelling. The best composition for the synthesis was obtained for sample B with the ratio of HA:TCP = 50:50. For sample B, the synthesized biocomposite has the density of 1.67790 gr/cm3, porosity of 78.64%, tension of 10.14 MPa, swelling ability  46.85% and the sample mass degradation percentage of 8.1 %. The composition used for the biocomposite synthesis in this research was suitable to be applied as bone filler material which needs a dense pores and high tension.

Keywords

Injectable bone subtitute; hydroxyapatite; Tricalcium phospate

References

Aoki, H., 1991. Science Medical Applications Of Hydroxyapatite, JAAS, Tokyo

DEPKES, 2009, Waspadai osteoporosis di Indonesia. http://www.depkes.co.id/index.php.html. diperoleh tanggal 26 Maret 2016

Hajrawati, 2006, Sifat Fisik dan Kimia Gelatin Tulang Sapi dengan Perendaman Asam Klorida pada Konsentrasi dan Lama Perendaman yang Berbeda, Thesis, Sekolah Pascasarjana Institut Pertanian Bogor, Indonesia

Kashiwazaki H., Yusuke K., Atsushi M., Keisuke Y., and Tadhasi I., 2009, Fabrication of porous chitosan/ hydroxyapatite nanocomposites: their mechanical and biological properties, Bio. Med. Mat. And Eng., 19, 133-140

Levin, M.P., Getter, L., and Cutright, D.E., 1975, A comparison of iliac marrow and biodegradable ceramic in periodontal defects. J. Biomed. Mater. Res. 9, 183

Perut, F., Montufar, E. B., Ciapetti, G., Santin, M., Salvage, J., Traykova, T., Planell, J. A. andGinebra, M. P., 2011, Novel Soybean/ Gelatin-Based Bioactive and Injectable Hydroxyapatite Foam: Material Properties and Cell Response, Acta Biomaterialia 7 Inc Elsevier Ltd, Italia: 1780-1787

Pierre, C., 2006, Injectable calcium phosphate scaffold and bone marrow graft for bone reconstruction in irradiated areas: An experimental study in rats, Biomaterials, 27, 4566-4572

Victoria, E.C., and Gnanam, F.D., 2012, Synthesis And Characterisation Of Biphasic Calcium Phosphate, Trends. Biomater. Artif. Organ, Vol.16 (1) PP 12-14

Wilman, G., 1996, Medical Grade Hydroxyapatite. State of The Art, Bristh Ceramic Transaction, Vol. 95. No 5

WHO., 2009.Osteoporosis ancaman kesehatan penduduk dunia. http://www.who.org/program/osteoporosis/index.html, Diakses pada tanggal 26 Maret 2016



Indonesian Journal of Chemical Research
ISSN 2354-9610 (print), ISSN 2614-5081 (online)
Published by:
Chemistry Department
Faculty of Mathematics and Natural Science
Universitas Islam Indonesia, Yogyakarta

Creative Commons License

Jurnal IJCR is licensed under a Creative Commons Attribution ShareAlike 4.0