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Abstract
ABSTRACT
Indonesia has a lot of traditional medicines, which people used long time ago, one of these
is mindi (Melia azedarach L.). It have been known that ethanolic extract of mindi leaves has
analgesic effect greater than paracetamol at dose 6.44 mg/kgBW and 12.89 mg/kgBW. This
research conducted to find out the effectiveness ethanolic fraction of ethanolic extract as an
analgesic. The research was carried out in completely random one way design, used 35 mice
which have been fasted for 24 hours. The mice were divided into 7 groups i.e. negative control,
positive control and 5 testing groups (in different doses). Fifteen minutes after injected with the
fractions of mindi, the mice were given acetic acid 0.5% intraperitoneally injection. The cumulative
writhe reflects were calculated in every 5 minutes for one hour and were counted the protection
percentage. Results showed that the ethanol fractions doses 12,88-103,04 mg/kgBW of mindi
leaves have the analgesic effect in mice and gave protection percentage 30.93-71.61%. The
chromatograms of TLC indicated that the fraction contain flavonoids and phenolic compounds.
Key words: ethanol fraction of mindi, analgesic effect, TLC profile