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Abstract
ABSTRACT
Brain barrier is effective barrier in drug delivery to brain. For effectiveness drug delivery
need be desaigned a delivery with nanoparticle technology. Nanoparticles are solid colloidal
particles ranging in size from 1 to 1000 nm that are utilized as drug delivery agents. The primary
advantages of nanoparticle carrier technology is that nanoparticles mask the blood – brain barrier
limiting characteristics of the therapeutic drug molecule. Furthermore, this system may slow drug
release in the brain, decreasing peripheral toxicity. The method which elaboration in manufacture
nanoparticles are emulsion polimerization, interfacial polimerization, desolvation evaporation and
solvent deposition. Currently, report evaluating nanoparticles for brain delivery have studied
anesthetic and chemoterapeutic agent. These studies are reviewed for efficacy and mechanisms of
transport. Physiological factors such as phagocytic activity of the reticuloendothelial system and
protein opsonization may limit the amount of brain delivered drug. Nanoparticle technology appears
to have significant promise in delivering therapeutic molecules across the blood-brain barrier.
Key Word : Drug Delivery System, Nanoparticle, Blood-Brain Barrier